The perimenopause, depressive disorders, and hormonal variability

Autores

  • Cláudio de Novaes Soares Center for Women’s Mental Health, Perinatal and Reproductive Psychiatry Clinical Research Program, Massachusetts General Hospital, Harvard Medical School
  • Lee Stuart Cohen Center for Women’s Mental Health, Perinatal and Reproductive Psychiatry Clinical Research Program, Massachusetts General Hospital, Harvard Medical School

Palavras-chave:

Peri-menopausa, Depressão, Revisão, Estrógenos, Tratamento

Resumo

CONTEXTO: Diversos trabalhos têm apontado a peri-menopausa como um período de maior vulnerabilidade para o surgimento de transtornos psiquiátricos, particularmente os quadros depressivos. Esse artigo revisa, primeiramente, o conceito de peri-menopausa, descrevendo suas características clínicas, alterações biológicas e aspectos psicossociais. Estudos sobre a prevalência de transtornos depressivos durante a peri-menopausa, abordando diferentes sub-populações (mulheres atendidas em serviços ginecológicos especializados, estudos populacionais transversais e longitudinais), são discutidos de forma crítica. Nesse artigo também abordamos as alterações hormonais presentes durante a transição menopausal, e o seu possível papel de “gatilho” no surgimento/exacerbação de quadros depressivos. Apresentamos um modelo de abordagem terapêutica para os quadros depressivos surgidos entre mulheres na faixa etária correspondente à peri-menopausa. O papel da terapêutica de reposição hormonal, nesses quadros, é discutido através da revisão dos estudos existentes sobre o uso de estrógenos como agente antidepressivo (monoterapia, terapêutica adjuvante ou profilaxia). TIPO DE ESTUDO: Revisão narrativa.

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Biografia do Autor

Cláudio de Novaes Soares, Center for Women’s Mental Health, Perinatal and Reproductive Psychiatry Clinical Research Program, Massachusetts General Hospital, Harvard Medical School

MD, PhD. Post-doctoral Research Fellow, Center for Women’s Mental Health, Perinatal and Reproductive Psychiatry Clinical Research Program, Massachusetts General Hospital, Harvard Medical School, USA. Sponsored by a scholarship from FAPESP, Brazil (99/ 08459-3).

Lee Stuart Cohen, Center for Women’s Mental Health, Perinatal and Reproductive Psychiatry Clinical Research Program, Massachusetts General Hospital, Harvard Medical School

MD. Associate Professor, Department of Psychiatry, Director, Center for Women’s Mental Health, Perinatal and Reproductive Psychiatry Clinical Research Program, Massachusetts General Hospital, Harvard Medical School, USA.

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Publicado

2001-03-03

Como Citar

1.
Soares C de N, Cohen LS. The perimenopause, depressive disorders, and hormonal variability. Sao Paulo Med J [Internet]. 3º de março de 2001 [citado 10º de março de 2025];119(2):78-83. Disponível em: https://periodicosapm.emnuvens.com.br/spmj/article/view/2748

Edição

v. 119 n. 2 (2001)

Seção

Artigo de Revisão

Licença

Creative Commons License
Este trabalho está licenciado sob uma licença Creative Commons Attribution 4.0 International License.