Short-term outcomes of COVID-19 in pregnant women unvaccinated for SARS-CoV-2 in the first, second, and third trimesters

a retrospective study

Autores

Palavras-chave:

COVID-19, SARS-CoV-2, Pregnancy, Intensive care units, neonatal

Resumo

BACKGROUND: Coronavirus disease 2019 (COVID-19) may be asymptomatic or symptomatic in pregnant women. Compared to non-pregnant reproductive-aged women, symptomatic individuals appear to have a higher risk of acquiring severe illness sequelae. OBJECTIVES: We assessed the clinical and laboratory characteristics and outcomes of pregnant COVID-19 patients unvaccinated for severe acute respiratory syndrome coronavirus 2 according to the trimester of pregnancy. DESIGN AND SETTING: This was a retrospective observational study conducted in a tertiary-level hospital in Turkey. METHODS: This retrospective study reviewed the clinical and laboratory characteristics and outcomes of 445 pregnant COVID-19 patients hospitalized during the first, second, and third trimesters of pregnancy and 149 other pregnant women as controls in a tertiary center from April 2020 to December 2021. All participants were unvaccinated. RESULTS: Overall, the study groups were comparable in terms of baseline clinical pregnancy characteristics. There was no clear difference among the study participants with COVID-19 in the first, second, and third trimesters of pregnancy. However, a considerably high number of clinical and laboratory findings revealed differences that were consistent with the inflammatory nature of the disease. CONCLUSIONS: The study results reveal the importance of careful follow-up of hospitalized cases as a necessary step by means of regular clinical and laboratory examinations in pregnant COVID-19 patients. With further studies, after implementing vaccination programs for COVID-19 in pregnant women, these data may help determine the impact of vaccination on the outcomes of pregnant COVID-19 patients.

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Biografia do Autor

Filiz Yarsilikal Guleroglu, Haseki Training and Research Hospital affiliated with Health Sciences University

MD. Perinatologist, Department of Obstetrics and Gynecology, Haseki Training and Research Hospital affiliated with Health Sciences University, Sultangazi, Istanbul, Turkey.

Hatice Argun Atalmis, Haseki Training and Research Hospital affiliated with Health Sciences University

MD. Obstetrician and Gynecologist, Department of Obstetrics and Gynecology, Haseki Training and Research Hospital affiliated with Health Sciences University, Sultangazi, Istanbul, Turkey.

Icten Olgu Bafali, Haseki Training and Research Hospital affiliated with Health Sciences University

MD. Obstetrician and Gynecologist, Department of Obstetrics and Gynecology, Haseki Training and Research Hospital affiliated with Health Sciences University, Sultangazi, Istanbul, Turkey.

Gulser Bingol Dikdere, Haseki Training and Research Hospital affiliated with Health Sciences University

MD. Obstetrician and Gynecologist, Department of Obstetrics and Gynecology, Haseki Training and Research Hospital affiliated with Health Sciences University, Sultangazi, Istanbul, Turkey.

Irfan Dikdere, Haseki Training and Research Hospital affiliated with Health Sciences University

MD. Obstetrician and Gynecologist, Department of Obstetrics and Gynecology, Haseki Training and Research Hospital affiliated with Health Sciences University, Sultangazi, Istanbul, Turkey.

Murat Ekmez, Haseki Training and Research Hospital affiliated with Health Sciences University

MD. Obstetrician and Gynecologist, Department of Obstetrics and Gynecology, Haseki Training and Research Hospital affiliated with Health Sciences University, Sultangazi, Istanbul, Turkey. 

Alpaslan Kaban

MD. Obstetrician and Gynecologist, Department of Obstetrics and Gynecology, Haseki Training and Research Hospital affiliated with Health Sciences University, Sultangazi, Istanbul, Turkey. 

Fatma Karasabanoglu, Haseki Training and Research Hospital affiliated with Health Sciences University

MD. Obstetrician and Gynecologist, Department of Obstetrics and Gynecology, Haseki Training and Research Hospital affiliated with Health Sciences University, Sultangazi, Istanbul, Turkey. 

Busra Seker Atas, Haseki Training and Research Hospital affiliated with Health Sciences University

MD. Obstetrician and Gynecologist, Department of Obstetrics and Gynecology, Haseki Training and Research Hospital affiliated with Health Sciences University, Sultangazi, Istanbul, Turkey.

Esra Selvi, Haseki Training and Research Hospital affiliated with Health Sciences University

MD. Obstetrician and Gynecologist, Department of Obstetrics and Gynecology, Haseki Training and Research Hospital affiliated with Health Sciences University, Sultangazi, Istanbul, Turkey.

Gulay Sumnu, Haseki Training and Research Hospital affiliated with Health Sciences University

MD. Obstetrician and Gynecologist, Department of Obstetrics and Gynecology, Haseki Training and Research Hospital affiliated with Health Sciences University, Sultangazi, Istanbul, Turkey.

Merve Topaktas, Haseki Training and Research Hospital affiliated with Health Sciences University

MD. Obstetrician and Gynecologist, Department of Obstetrics and Gynecology, Haseki Training and Research Hospital affiliated with Health Sciences University, Sultangazi, Istanbul, Turkey.

Merve Yasti Dayan, Haseki Training and Research Hospital affiliated with Health Sciences University

MD. Obstetrician and Gynecologist, Department of Obstetrics and Gynecology, Haseki Training and Research Hospital affiliated with Health Sciences University, Sultangazi, Istanbul, Turkey.

Sevilay Yavuz Dogu, Haseki Training and Research Hospital affiliated with Health Sciences University

MD. Obstetrician and Gynecologist, Department of Obstetrics and Gynecology, Haseki Training and Research Hospital affiliated with Health Sciences University, Sultangazi, Istanbul, Turkey. 

Ali Cetin, Haseki Training and Research Hospital affiliated with Health Sciences University

MD, PhD. Perinatologist, Department of Obstetrics and Gynecology, Haseki Training and Research Hospital affiliated with Health Sciences University, Sultangazi, Istanbul, Turkey.

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Publicado

2023-06-27

Como Citar

1.
Guleroglu FY, Atalmis HA, Bafali IO, Dikdere GB, Dikdere I, Ekmez M, Kaban A, Karasabanoglu F, Atas BS, Selvi E, Sumnu G, Topaktas M, Dayan MY, Dogu SY, Cetin A. Short-term outcomes of COVID-19 in pregnant women unvaccinated for SARS-CoV-2 in the first, second, and third trimesters: a retrospective study. Sao Paulo Med J [Internet]. 27º de junho de 2023 [citado 14º de março de 2025];141(4):1-9. Disponível em: https://periodicosapm.emnuvens.com.br/spmj/article/view/500

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