Retroperitoneal unicentric Castleman’s disease (giant lymph node hyperplasia)

case report

Authors

  • Jaques Waisberg Hospital do Servidor Público Estadual de São Paulo
  • Marie Satake Hospital do Servidor Público Estadual de São Paulo
  • Nagamassa Yamagushi Hospital do Servidor Público Estadual de São Paulo
  • Leandro Luongo de Matos Hospital do Servidor Público Estadual de São Paulo
  • Daniel Reis Waisberg Hospital do Servidor Público Estadual de São Paulo
  • Ricardo Artigiani Neto Hospital do Servidor Público Estadual de São Paulo
  • Maria Isete Fares Franco Hospital do Servidor Público Estadual de São Paulo

Keywords:

Castleman disease, Retroperitoneal neoplasms, Lymphatic system, Lymphoproliferative disorders, Retroperitoneal space

Abstract

CONTEXT AND OBJECTIVE: Castleman’s disease, or giant lymph node hyperplasia, is a rare disorder of the lymphoid tissue that causes lymph node enlargement. It is considered benign in its localized form, but aggressive in the multicentric type. The defi nitive diagnosis is based on postoperative pathological fi ndings. The aim here was to describe a case of retroperitoneal unicentric Castleman’s disease in the retroperitoneum. CASE REPORT: A 61-year-old white male with weight loss and listlessness presented with moderate arterial hypertension and leukopenia. Abdominal tomography revealed a 5 x 4 x 5 cm oval mass of low attenuation, with inner calcifi - cation and intense enhancement on intravenous contrast, located in the retroperitoneal region, between the left kidney and the aorta, at the renal hilus. Exploratory laparotomy revealed a non-pulsatile solid oval mass situated in the retroperitoneum, adjacent to the left renal hilus. The retroperitoneal lesion was removed in its entirety. Examination of frozen samples revealed benign lymph node tissue and histopathological examination of the surgical sample revealed hyaline-vascular giant lymph node hyperplasia (Castleman’s disease). The patient was discharged on the 12th day without signifi cant events. Two months after the operation, the patient was readmitted with severe cardiac insuffi ciency, acute renal failure and bronchopneumonia, which progressed to acute respiratory insuffi ciency, sepsis and death.

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Author Biographies

Jaques Waisberg, Hospital do Servidor Público Estadual de São Paulo

MD, PhD. Department of Surgery, Hospital do Servidor Público Estadual de São Paulo, São Paulo, Brazil.

Marie Satake, Hospital do Servidor Público Estadual de São Paulo

MD, MSc. Department of Hematology, Hospital do Servidor Público Estadual de São Paulo, São Paulo, Brazil.

Nagamassa Yamagushi, Hospital do Servidor Público Estadual de São Paulo

MD, PhD. Department of Surgery, Hospital do Servidor Público Estadual de São Paulo, São Paulo, Brazil.

Leandro Luongo de Matos, Hospital do Servidor Público Estadual de São Paulo

Undergraduate student, Faculdade de Medicina do ABC (FMABC), SantoAndré, SãoPaulo, Brazil.

Daniel Reis Waisberg, Hospital do Servidor Público Estadual de São Paulo

Undergraduate student, Faculdade de Medicina da Universidade de São Paulo (FMUSP), São Paulo, Brazil.

Ricardo Artigiani Neto, Hospital do Servidor Público Estadual de São Paulo

MD, MSc. Department of Pathology, Hospital do Servidor Público Estadual de São Paulo, São Paulo, Brazil.

Maria Isete Fares Franco, Hospital do Servidor Público Estadual de São Paulo

MD, PhD. Department of Pathology, Hospital do Servidor Público Estadual de São Paulo, São Paulo, Brazil.

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Published

2007-07-07

How to Cite

1.
Waisberg J, Satake M, Yamagushi N, Matos LL de, Waisberg DR, Artigiani Neto R, Franco MIF. Retroperitoneal unicentric Castleman’s disease (giant lymph node hyperplasia): case report. Sao Paulo Med J [Internet]. 2007 Jul. 7 [cited 2025 Mar. 17];125(4):253-5. Available from: https://periodicosapm.emnuvens.com.br/spmj/article/view/2126

Issue

Section

Case Report