Histological classification of 1,025 cases of Hodgkin’s lymphoma from the State of São Paulo, Brazil
Keywords:
Hodgkin’s disease, Pathology, Classification, Lymphoma, NeoplasmsAbstract
CONTEXT AND OBJECTIVE: It is currently asserted that, in industrialized countries, nodular sclerosis is the most frequent type of Hodgkin’s lymphoma, in contrast to developing countries, where mixed cellularity and lymphocyte depletion are more frequently seen. The objective was to review histological data from cases of Hodgkin’s lymphoma from São Paulo and Campinas cities. DESIGN AND SETTING: Cross-sectional histo- pathological analysis, in four university hospitals and one cancer care center. METHODS: 1,025 cases diagnosed as Hodgkin’s lymphoma between 1990 and 2000 were col- lected from five institutions; 631 of them (61.5%) had been immunophenotyped using antibodies to CD20, CD3, CD15 and CD30. The relative frequencies of histological types (as informed by the contributing authors, who are hematopathologists in their institutions) were determined according to age and gender. RESULTS: The Hodgkin’s lymphoma types were distributed as follows: lymphocyte predominance 4.8%, nodular sclerosis 69.2%, mixed cellularity 21.1% and lymphocyte depletion 4.6%. CONCLUSIONS: The controversy regarding the frequencies of Hodgkin’s lymphoma types within the Brazilian setting seems to be due to the small number of cases in previous studies. The present data show a picture close to the situation in the industrialized countries.
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References
Correa P, O’Conor GT. Geographic pathology of lymphoreticu- lar tumors: summary of survey from the geographic pathology committee of the international union against cancer. J Natl Cancer Inst. 1973;50(6):1609-17.
Faria SL, Vassallo J, Cosset JM, Brandalise SR. Childhood Hodgkin’s disease in Campinas, Brazil. Med Pediatr Oncol. 1996;26(2);90-4.
de Souza CA, Vassallo J, Lorand-Metze I. Hodgkin’s disease in Brazil: a clinicopathologic study. Haematologica. 1997; 82(1):127-8.
Spector N, Costa MA, Pulcheri W, et al. C-MOPP/ABV yields good results in a public hospital population with Hodgkin disease in Brazil. Cancer. 1993;71(9):2823-7.
Spector N, Nucci M, Oliveira De Morais JC, et al. Clinical factors predictive of bone marrow involvement in Hodgkin’s disease. Leuk Lymphoma. 1997;26(1-2):171-6.
Spector N, Costa MA, Morais JC, et al. Intensified ABVP chemotherapy for the primary treatment of Hodgkin’s disease. Oncol Rep. 2002;9(2):439-42.
Vassallo J, Metze K, Traina F, de Souza CA, Lorand-Metze I. Ex- pression of Epstein-Barr virus in classical Hodgkin’s lymphomas in Brazilian adult patients. Haematologica. 2001;86(11):1227-8.
Elgui de Oliveira D, Bacchi MM, Abreu ES, Niero-Melo L, Bacchi CE. Hodgkin disease in adult and juvenile groups from two different geographic regions in Brazil: characterization of clinicopathologic aspects and relationship with Epstein-Barr virus infection. Am J Clin Pathol. 2002;118(1):25-30.
Jaffe ES, Harris NL, Stein H, Vardiman JW, editors. World Health Organization Classification of Tumors. Pathology and Genetics of Tumours of Hematopoietic and Lymphoid Tissues. Lyon: IARC Press; 2001.
Kennedy BJ, Fremgen AM, Menck HR. The National Cancer Data Base report on Hodgkin’s disease for 1985-1989 and 1990-1994. Cancer. 1998;83(5):1041-7.
Glaser SL, Dorfman RF, Clarke CA. Expert review of the diagnosis and histologic classification of Hodgkin disease in a population- based cancer registry: interobserver reliability and impact on incidence and survival rates. Cancer. 2001;92(2):218-24.
