Meigs’ syndrome with elevated CA 125

case report

Authors

  • Sabas Carlos Vieira Hospital São Marcos
  • Leonardo Halley Carvalho Pimentel Hospital São Marcos
  • José Carlos Castelo Branco Ribeiro Hospital São Marcos
  • Argemiro Ferreira de Andrade Neto Hospital São Marcos
  • Jerúsia Oliveira Ibiapina de Santana Hospital São Marcos

Keywords:

Meigs’ syndrome, CA 125 Antigen, Ovarian tumor, Ovarian carcinoma, Thecoma

Abstract

CONTEXT: Meigs’ syndrome consists of a benign ovarian tumor accompanied by ascites and hydrothorax. Elevated serum CA 125 levels in postmeno-pausal women with solid adnexal masses, ascites and pleural effusion are highly suggestive for malignant ovarian tumor. However, patients with Meigs’ syndrome can also have elevated serum CA 125 levels. The authors report a case of Meigs’ syndrome with elevated CA 125 level. OBJECTIVE: This is a case report of Meigs’ syndrome with elevated CA 125 level. CASE REPORT: A 65-year-old Brazilian woman had presented progressive dyspnea, weight loss and decline in general condition over the 7 months preceding admission to our service. In another hospital, the patient had been submitted to thoracic drainage due to pleural effusion. With recurrence of the pleural effusion and increase in abdominal volume due to ascites and a pelvic mass, the patient sought our service. Transvaginal ultrasound showed an extensive adnexal solid mass of 16.4 x 10.8 cm located in the pelvis without exact limits, and the serum CA 125 level was elevated. With a preoperative diagnosis of ovarian carcinoma, the patient was submitted to exploratory laparotomy, which revealed a left ovarian tumor. The frozen section diagnosis was thecoma. Total abdominal hysterectomy with bilateral salpingo-oophorectomy was performed. The histology of the specimen confirmed the diagnosis of thecoma. The patient was asymptomatic with a normal serum CA 125 level 20 months after the operation.

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Author Biographies

Sabas Carlos Vieira, Hospital São Marcos

MD. Auxiliary Professor, School of Medicine, Universidade Federal do Piauí, Piauí, Brazil.

Leonardo Halley Carvalho Pimentel, Hospital São Marcos

MD. Graduate of Universidade Federal do Piauí, Piauí, Brazil.

José Carlos Castelo Branco Ribeiro, Hospital São Marcos

Undergraduate Student, School of Medicine, Universidade Federal do Piauí, Piauí, Brazil.

Argemiro Ferreira de Andrade Neto, Hospital São Marcos

Undergraduate Student, School of Medicine, Universidade Federal do Piauí, Piauí, Brazil.

Jerúsia Oliveira Ibiapina de Santana, Hospital São Marcos

MD. Pathologist, Hospital São Marcos, Teresina, Piauí, Brazil.

References

Abad A, Cazorla E, Ruiz F, et al. Meigs’ syndrome with elevated CA 125: case report and review of the literature. Eur J Obstet Gynecol Reprod Biol 1999;82(1):97-9.0

Turan YH, Demirel LC, Ortac F. Elevated CA 125 in Meigs syndrome. Int J Gynaecol Obstet 1993;43(1):64-5.

Agranoff D, May D, Jameson C, Knowles GK. Pleural effusion and a pelvic mass. Postgrad Med J 1998;74(871):265-7.

Niloff JM, Knapp RC, Schaetzl E, Reynolds C, Bast RC. CA125 antigen levels in obstetric and gynecologic patients. Obstet Gynecol 1984;64(5):703-7.

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Published

2003-09-09

How to Cite

1.
Vieira SC, Pimentel LHC, Ribeiro JCCB, Andrade Neto AF de, Santana JOI de. Meigs’ syndrome with elevated CA 125: case report. Sao Paulo Med J [Internet]. 2003 Sep. 9 [cited 2025 Mar. 15];121(5):210-2. Available from: https://periodicosapm.emnuvens.com.br/spmj/article/view/2640

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Section

Case Report