ABO, Lewis, secretor and non-secretor phenotypes in patients infected or uninfected by the Helicobacter pylori bacillus

Authors

  • Luiz Carlos de Mattos Faculty of Medicine of São José do Rio Preto
  • Juliana Rodrigues Cintra Faculty of Medicine of São José do Rio Preto
  • Fábio Eduardo Sanches Faculty of Medicine of São José do Rio Preto
  • Rita de Cássia Martins Alves da Silva Faculty of Medicine of São José do Rio Preto
  • Milton Artur Ruiz Faculty of Medicine of São José do Rio Preto
  • Haroldo Wilson Moreira Faculty of Medicine of São José do Rio Preto

Keywords:

Blood groups, ABO, Lewis, Secretor phenotype, Non-secretor phenotype, Helicobacter pylori

Abstract

CONTEXT: Epidemiological studies have demonstrated higher frequencies of the O blood group and the non-secretor phenotype of ABH antigens among patients suffering from peptic ulcers. Since Helicobacter pylori has been established as the main etiological factor in this disease, contro-versies about the associations of the ABO and Lewis blood group phenotypes and secretor and non-secretor phenotypes in relation to susceptibility towards infection by this bacillus have been presented. OBJECTIVE: To verify the frequencies of ABO, Lewis blood group phenotypes, secretor and non-secretor phenotypes in patients infected or uninfected by H. pylori. DESIGN: Cross-sectional study. SETTING: Outpatient clinic. PARTICIPANTS: One hundred and twenty patients with dyspeptic symptoms who underwent endoscopy. MAIN MEASUREMENTS: ABO and Lewis blood group phenotypes were determined by a standard hemagglutination test and the secretor and non-secretor phenotypes were evaluated by saliva samples using the inhibitor hemagglutination test. RESULTS: The diagnosis of infection, made via breath and urea tests and confirmed using polymerase chain reaction (PCR) in gastric biopsy fragments, showed the presence of H. pylori in 61.7% of the patients and absence in 38.3%. The differences between the frequencies of the ABO blood group phenotypes among infected (A 27.0%; B 12.2%; AB 4.0% and O 56.8%) and uninfected patients (A 58.7%; B 13.0%; AB 4.3% and O 24.0%) were significant. The Lewis blood type, secretor and non-secretor phenotypes showed homogeneous distribution between the groups of patients analyzed. CONCLUSIONS: Our results suggest that the infection of H. pylori can be related to ABO blood groups but not to the Lewis blood group nor to secretor and non-secretor phenotypes.

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Author Biographies

Luiz Carlos de Mattos, Faculty of Medicine of São José do Rio Preto

MD, PhD. Associate Professor, Department of Molecular Biology, Faculty of Medicine of São José do Rio Preto; Director of the Molecular Immunogenetic Laboratory, Hemocenter of São José do Rio Preto, São José do Rio Preto, Brazil.

Juliana Rodrigues Cintra, Faculty of Medicine of São José do Rio Preto

Biologist at the Molecular Immunogenetic Laboratory, Hemocenter of São José do Rio Preto, São José do Rio Preto, Brazil.

Fábio Eduardo Sanches, Faculty of Medicine of São José do Rio Preto

Medical Biologist at the Molecular Immunogenetic Laboratory, Hemocenter of São José do Rio Preto, São José do Rio Preto, Brazil.

Rita de Cássia Martins Alves da Silva, Faculty of Medicine of São José do Rio Preto

MD, PhD. Associate Professor, Department of Internal Medicine of the Faculty of Medicine of São José do Rio Preto; Director of the specialized Gastroenterology Laboratory of the Hospital of Base/FUNFARME, São José do Rio Preto, Brazil.

Milton Artur Ruiz, Faculty of Medicine of São José do Rio Preto

MD. PhD. Associate Professor, Department of Internal Medicine, Faculty of Medicine of São José do Rio Preto; Coordinator of the Bone Marrow Transplant Unit, Hospital of Base/FUNFARME, São José do Rio Preto, Brazil.

Haroldo Wilson Moreira, Faculty of Medicine of São José do Rio Preto

MD, PhD. Professor, Department of Clinical Analyses, Faculty of Pharmaceutical Sciences, São Paulo State University, Araraquara Campus, São Paulo, Brazil.

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Published

2002-03-03

How to Cite

1.
Mattos LC de, Cintra JR, Sanches FE, Silva R de CMA da, Ruiz MA, Moreira HW. ABO, Lewis, secretor and non-secretor phenotypes in patients infected or uninfected by the Helicobacter pylori bacillus. Sao Paulo Med J [Internet]. 2002 Mar. 3 [cited 2025 Oct. 16];120(2):55-8. Available from: https://periodicosapm.emnuvens.com.br/spmj/article/view/2677

Issue

Vol. 120 No. 2 (2002)

Section

Original Article

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